Understanding how growth factors affect stem cells in the adult testis
Negative feedback regulation of growth factor signaling in adult spermatogonial stem cells
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11036247
This study is looking at how certain proteins help keep sperm-producing stem cells healthy and functioning properly, which could lead to better ways to support fertility in men.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11036247 on ClinicalTrials.gov |
What this research studies
This research investigates the role of negative feedback regulators in controlling growth factor signaling in adult spermatogonial stem cells (SSCs). By using genetic mouse models and advanced biosensors, the study aims to uncover how these regulators maintain SSC self-renewal and prevent premature differentiation. The research will explore the cellular mechanisms that allow SSCs to thrive in their natural environment and how disruptions in these processes can affect fertility. Patients may benefit from insights gained about SSC function and fertility preservation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are adult males experiencing difficulties with fertility or those interested in understanding stem cell dynamics.
Not a fit: Patients who are not male or those who do not have concerns related to fertility may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preserving male fertility and enhancing the understanding of stem cell biology.
How similar studies have performed: Previous research has shown success in understanding growth factor signaling in stem cells, but this specific approach focusing on negative feedback regulation is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EVANS, TODD R — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: EVANS, TODD R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.