Understanding how groups of neurons control behavior in a simple animal.
Official title: Neuronal Ensemble Mechanisms of Behavior and Plasticity in a Cnidarian
Funded at Columbia Univ New York Morningside · NIH-11139072 · Data updated 2026-11-12
This study is looking at how groups of brain cells work together to affect behaviors and feelings, especially in conditions like Alzheimer's and autism, by using a simple creature called Hydra to learn more about how these brain cells control feeding behavior.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $246,750 |
| NIH project number | 1R21NS135654-01A1 |
| Project ID | NIH-11139072 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by neurological conditions such as Alzheimer's disease or autism spectrum disorders.
✕Less likely to help
Patients with conditions unrelated to neuronal ensemble dysfunction or those not affected by neurological disorders may not benefit from this research.
What this research studies
This research investigates how groups of neurons, known as neuronal ensembles, influence specific behaviors and mental states, particularly in relation to behavioral disorders like Alzheimer's and autism. Using the cnidarian Hydra vulgaris, researchers will explore the neuronal circuits involved in feeding behavior by recording and stimulating neuronal activity. The study aims to uncover the interactions between different neuronal ensembles to better understand their role in behavior and potential therapeutic targets for neurological conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and therapies for various neurological and behavioral disorders.
How similar studies have gone: While the approach of studying neuronal ensembles is established, the specific application to Hydra vulgaris represents a novel exploration in this area.
Where this research is happening
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Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Yuste, Rafael — Columbia Univ New York Morningside
- Study coordinator: Yuste, Rafael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.