Understanding how Group B Streptococcus persists in the female genital tract
Host and bacterial mechanisms governing Group B streptococcal persistence in the female genital tract
This study is looking at how Group B Streptococcus (GBS) bacteria stick around in the female genital area and how that might lead to problems during pregnancy, like preterm birth or stillbirth, so we can find ways to help keep moms and babies safe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11036396 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which Group B Streptococcus (GBS) bacteria persist in the female genital tract and how this persistence can lead to adverse pregnancy outcomes such as preterm birth and stillbirth. The study focuses on three main areas: how GBS adheres to host cells, how it competes with the normal vaginal microbiota, and how it evades the host's immune responses. By examining these interactions, the research aims to uncover the dynamic factors that influence GBS colonization and its potential to ascend to the uterus. This could provide insights into preventing infections that threaten pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women or those planning to become pregnant who may be at risk for GBS colonization.
Not a fit: Patients who are not pregnant or do not have a history of GBS colonization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing preterm birth and stillbirth associated with GBS infections.
How similar studies have performed: Previous research has shown success in understanding bacterial interactions in the female genital tract, but the specific mechanisms of GBS persistence are still being explored.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Doran, Kelly S — University of Colorado Denver
- Study coordinator: Doran, Kelly S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.