Understanding how Group B Streptococcus interacts with the human microbiome
Official title: Function of the type 7 secretion system in Group B Streptococcus
Funded at University of Kentucky · NIH-10735898 · Data updated 2026-11-12
This study is looking at how a bacteria called Group B Streptococcus (GBS) sticks to and invades human cells, especially in older adults and those with weakened immune systems, to help find better ways to treat infections caused by it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | November 7, 2022 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $195,543 |
| NIH project number | 5R21AI169231-02 |
| Project ID | NIH-10735898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults, especially those who are elderly or immunocompromised, who may be at risk for infections caused by Group B Streptococcus.
✕Less likely to help
Patients who are healthy and do not have risk factors for Group B Streptococcus infections may not receive benefit from this research.
What this research studies
This research investigates the role of the Type VII secretion system in Group B Streptococcus (GBS), a bacterium that can cause serious infections in adults, particularly the elderly and immunocompromised individuals. The study aims to understand how GBS adheres to and invades human vaginal cells, as well as how it competes with other bacteria in the microbiome. Using in vitro human cell lines and mouse models, researchers will analyze the mechanisms by which GBS establishes itself and interacts with the host's immune responses. This could lead to better understanding of GBS infections and potential new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for infections caused by Group B Streptococcus, particularly in vulnerable populations.
How similar studies have gone: Previous research has shown success in understanding bacterial interactions within the microbiome, making this approach promising for further insights into GBS.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Korotkov, Konstantin V — University of Kentucky
- Study coordinator: Korotkov, Konstantin V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.