Understanding how Group B Streptococcus and Candida albicans interact in the body
Official title: Characterization of Interkingdom Synergy between Group B Streptococcus and Candida albicans
Funded at University of Colorado Denver · NIH-11069343 · Data updated 2026-11-12
This study is looking at how two germs, Group B Streptococcus and Candida, interact with each other in pregnant women and how this might affect the health of both moms and their babies, using mice to help understand the risks better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | November 14, 2024 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $216,264 |
| NIH project number | 1R21AI188719-01 |
| Project ID | NIH-11069343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women or those planning to become pregnant, particularly those with a history of GBS or Candida infections.
✕Less likely to help
Patients who are not pregnant or do not have a history of GBS or Candida infections may not benefit from this research.
What this research studies
This research investigates the interactions between Group B Streptococcus (GBS) and Candida albicans, two microorganisms that can affect health, particularly during pregnancy. The study aims to understand how these organisms coexist in the gastrointestinal and reproductive tracts and how their interactions may lead to adverse pregnancy outcomes and neonatal infections. By using a mouse model, researchers will explore how co-colonization with Candida can influence the behavior of GBS, potentially leading to increased risks for mothers and their babies. The findings could provide insights into preventing infections associated with these pathogens.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing infections during pregnancy and reducing risks for newborns.
How similar studies have gone: While the interactions between GBS and Candida albicans are not extensively studied, there is emerging evidence suggesting that understanding these relationships could lead to significant advancements in maternal and neonatal health.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Doran, Kelly S — University of Colorado Denver
- Study coordinator: Doran, Kelly S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.