Understanding how Gram-negative bacteria develop resistance to antibiotics
Comparative resistomics of Gram-negative bacterial pathogens
This study is looking at how certain harmful bacteria, like Acinetobacter baumannii, become resistant to antibiotics, and it's for anyone interested in understanding how we can improve treatments for bacterial infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11001489 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which Gram-negative bacterial pathogens, such as Acinetobacter baumannii, acquire and maintain resistance to antibiotics. By using a specialized device called a morbidostat, researchers will continuously culture bacteria and analyze their genetic changes over time through advanced genomic sequencing. This approach aims to uncover both universal and specific pathways of antibiotic resistance, providing insights that could lead to more effective treatments for bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by antibiotic-resistant Gram-negative bacteria.
Not a fit: Patients with infections caused by Gram-positive bacteria or those not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating antibiotic-resistant infections, improving treatment outcomes for patients.
How similar studies have performed: Previous studies have shown promise in understanding antibiotic resistance through similar experimental approaches, indicating potential for success in this research.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Osterman, Andrei L — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Osterman, Andrei L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.