Understanding how GPR37L1 controls seizure and migraine risk
Control of Seizure and Migraine Susceptibility by GPR37L1
This project explores how a specific gene, GPR37L1, contributes to the risk of developing both epilepsy and migraine, especially when they occur together in families.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11127563 on NIH RePORTER |
What this research studies
We know that epilepsy and migraine often run together in families, and recent human genetic findings point to the GPR37L1 gene as a key player. This gene is mainly active in brain cells called astrocytes, so understanding it better could show us how astrocyte problems lead to these conditions. Our goal is to uncover exactly how GPR37L1 works at a cellular level to influence seizure and migraine risk. We will look at how different versions of GPR37L1 linked to disease behave in astrocytes and why its signaling depends on these cells. We will also use models to see how these gene changes affect seizure vulnerability and brain development.
Who could benefit from this research
Good fit: This foundational research is most relevant to individuals with epilepsy and migraine, particularly those with a family history where both conditions are present.
Not a fit: Patients whose epilepsy or migraine is not linked to genetic factors or GPR37L1 may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new insights into the fundamental causes of epilepsy and migraine, potentially paving the way for new treatments for patients who experience both conditions.
How similar studies have performed: Previous human genetic studies have identified GPR37L1 as a contributor to epilepsy and migraine risk, providing a strong foundation for this novel mechanistic investigation.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Hall, Randy a. — Emory University
- Study coordinator: Hall, Randy a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.