Understanding how Gpr116 affects kidney acid regulation
Official title: Gpr116 Regulation of Renal Acid Excretion
Funded at University of New Mexico Health Scis Ctr · NIH-11012295 · Data updated 2026-11-12
This study is looking at a protein called Gpr116 in the kidneys to see how it helps control the balance of acids in the body, using mice to learn more about how this might lead to better treatments for kidney-related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | April 15, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00DK127215-05 |
| Project ID | NIH-11012295 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting kidney function or acid-base balance.
✕Less likely to help
Patients with unrelated kidney issues or those not experiencing acid-base imbalances may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, Gpr116, in the kidneys and how it regulates the excretion of acids. By studying mice with altered Gpr116 levels, researchers aim to uncover its function in maintaining acid-base balance in the body. The approach involves advanced genetic techniques to observe changes in urine and blood chemistry, which could provide insights into kidney function and potential treatments for related disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for kidney-related acid-base disorders, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding GPCRs and their roles in various physiological processes, indicating potential for success in this area.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Zaidman, Nathan a — University of New Mexico Health Scis Ctr
- Study coordinator: Zaidman, Nathan a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.