Understanding how gonorrhea bacteria survive and resist treatment
Targeting the functions of the gonococcal Type lV pilus
This study is looking at how the gonorrhea bacteria can dodge the immune system and resist antibiotics, and it hopes to find new treatments by testing small molecules that could help stop the bacteria from surviving.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10663812 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which Neisseria gonorrhoeae, the bacteria causing gonorrhea, uses its Type IV pilus to evade the immune system and resist antibiotic treatment. The study aims to explore how this pilus alters iron levels within the bacteria, helping it survive attacks from immune cells. Additionally, researchers will screen for small molecules that can inhibit a specific protease involved in the bacteria's survival, potentially leading to new treatments for gonorrhea and similar infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with gonorrhea or those at high risk of contracting the infection.
Not a fit: Patients who do not have gonorrhea or are not at risk for sexually transmitted infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics or treatments that effectively combat gonorrhea and reduce antibiotic resistance.
How similar studies have performed: Other research has shown promise in targeting bacterial virulence factors and developing new antibiotics, indicating that this approach could be effective.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Seifert, Hank S. — Northwestern University at Chicago
- Study coordinator: Seifert, Hank S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.