Understanding how gonorrhea bacteria colonize immune cells
Mechanism of macrophages colonization in gonorrhea
['FUNDING_R01'] · LOUISIANA STATE UNIV HSC SHREVEPORT · NIH-11090560
This study is looking at how the bacteria that cause gonorrhea manage to hide from our immune system by living inside certain immune cells, and it aims to help us understand how this happens so we can better tackle the infection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOUISIANA STATE UNIV HSC SHREVEPORT (nih funded) |
| Locations | 1 site (SHREVEPORT, UNITED STATES) |
| Trial ID | NIH-11090560 on ClinicalTrials.gov |
What this research studies
This research investigates how the bacteria Neisseria gonorrhoeae colonize macrophages, which are immune cells, during gonorrhea infections. The study aims to uncover the mechanisms by which these bacteria evade the immune response and establish themselves within these cells. By examining the interactions between the bacteria and the immune system, the research seeks to identify specific host receptors and bacterial components involved in this colonization process. The findings could provide insights into how gonorrhea develops and persists in the human body.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with gonorrhea, especially those with antibiotic-resistant infections.
Not a fit: Patients who do not have gonorrhea or are not infected with Neisseria gonorrhoeae may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing gonorrhea, particularly in cases involving antibiotic-resistant strains.
How similar studies have performed: Previous research has shown success in understanding bacterial colonization mechanisms, but this specific approach to studying Neisseria gonorrhoeae in macrophages is relatively novel.
Where this research is happening
SHREVEPORT, UNITED STATES
- LOUISIANA STATE UNIV HSC SHREVEPORT — SHREVEPORT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DRAGOI, ANA-MARIA — LOUISIANA STATE UNIV HSC SHREVEPORT
- Study coordinator: DRAGOI, ANA-MARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.