Understanding how GNAS mutations drive pancreatic cancer growth
Investigating the molecular mechanisms of growth in GNAS mutant pancreatic cancer.
This study is looking at how changes in a gene called GNAS might influence the growth of pancreatic cancer cells, with the hope that understanding this could help develop new treatments for patients with this type of cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10887401 on NIH RePORTER |
What this research studies
This research investigates the role of GNAS mutations in pancreatic ductal adenocarcinoma (PDA), a deadly form of cancer. By using a specialized mouse model, the study aims to uncover how these mutations affect cancer cell growth and metabolism. The researchers are particularly focused on how GNAS interacts with other oncogenes and the metabolic pathways that support tumor development. This could lead to new treatment strategies targeting these specific pathways in patients with GNAS-mutant tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma, particularly those with GNAS mutations.
Not a fit: Patients with pancreatic cancer that do not have GNAS mutations may not benefit from the findings of this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve outcomes for patients with GNAS-mutant pancreatic cancer.
How similar studies have performed: Other research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could be effective.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Patra, Krushna Chandra — University of Cincinnati
- Study coordinator: Patra, Krushna Chandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.