Understanding how GNAS mutations affect cancer spread in the abdomen
Official title: Defining the role of GNAS in gastrointestinal metastasis
Funded at Sloan-Kettering Inst Can Research · NIH-11053550 · Data updated 2026-11-12
This study is looking at how changes in a gene called GNAS affect gastrointestinal cancers that spread to the abdominal area, with the goal of finding out why these cancers are tough to treat and how we can improve treatments for patients facing this challenge.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $268,826 |
| NIH project number | 5K08CA279922-03 |
| Project ID | NIH-11053550 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with gastrointestinal cancers, particularly those with GNAS mutations and peritoneal metastases.
✕Less likely to help
Patients without gastrointestinal cancers or those whose tumors do not have GNAS mutations may not benefit from this research.
What this research studies
This research investigates the role of GNAS mutations in gastrointestinal cancers that spread to the peritoneal cavity, which is a common and serious complication. By analyzing tumor samples and using patient-derived organoids, the study aims to uncover the molecular mechanisms that enable these cancers to metastasize and resist chemotherapy. The researchers will explore how GNAS mutations influence specific signaling pathways that may contribute to tumor growth and spread. This work could lead to better understanding and treatment strategies for patients with these aggressive cancers.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with gastrointestinal cancers that have metastasized to the peritoneal cavity.
How similar studies have gone: Other research has shown promising results in understanding the role of genetic mutations in cancer metastasis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Foote, Michael — Sloan-Kettering Inst Can Research
- Study coordinator: Foote, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.