Understanding how glycoproteins and proteoglycans affect cell functions
Bridging the Glycome and Proteome with Chemical Biology
This study is looking at special molecules in our bodies that help cells communicate and work together, and the researchers want to create new versions of these molecules to see how they interact in living cells, which could help find better ways to treat diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11115600 on NIH RePORTER |
What this research studies
This research investigates the roles of glycoproteins and proteoglycans, which are essential molecules that influence various biological processes such as cell signaling, adhesion, and differentiation. By integrating chemical biology and molecular biology techniques, the researchers aim to create semi-synthetic versions of these molecules to study their interactions within live cells. This approach seeks to uncover how these molecules work together, which could lead to new strategies for drug discovery and treatment of diseases like cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancer or other conditions where glycoprotein interactions play a significant role in disease progression.
Not a fit: Patients with conditions unrelated to glycoprotein or proteoglycan functions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve treatment outcomes for patients with cancer and other diseases influenced by glycoproteins.
How similar studies have performed: Previous research has shown promise in understanding glycoprotein interactions, but this approach of creating semi-synthetic versions for live cell studies is relatively novel.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Huang, Mia L — Scripps Research Institute, the
- Study coordinator: Huang, Mia L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.