Understanding how glycine receptors affect neurodevelopmental disorders like autism
Official title: Investigating the Structural Basis of Human Glycine Receptor Modulation for Neurodevelopmental Disorders
Funded at Case Western Reserve University · NIH-11077670 · Data updated 2026-11-12
This study is looking at a special brain protein that plays a big role in conditions like autism, to see how changes in this protein and certain fats in the body might affect its function, which could help find new ways to improve symptoms for people with these challenges.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | March 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $54,538 |
| NIH project number | 5F30HD114399-02 |
| Project ID | NIH-11077670 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related neurodevelopmental disorders.
✕Less likely to help
Patients without neurodevelopmental disorders or those who do not have mutations affecting glycine receptors may not benefit from this research.
What this research studies
This research investigates the glycine receptor alpha 2 (GlyRα2), which is crucial for brain function and has been linked to neurodevelopmental disorders such as autism spectrum disorder. The study aims to explore how mutations in this receptor affect its function and how lipid molecules influence its activity. Using advanced techniques like cryogenic electron microscopy and patch-clamp electrophysiology, researchers will analyze the structural changes in GlyRα2 when it binds to glycine. This research could provide insights into potential therapeutic targets for improving symptoms in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate symptoms of autism spectrum disorder and related conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of glycine receptors in neurodevelopment, indicating that this approach has potential for success.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Krueger, Emily — Case Western Reserve University
- Study coordinator: Krueger, Emily
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.