Understanding how glycine receptors affect neurodevelopmental disorders like autism
Investigating the Structural Basis of Human Glycine Receptor Modulation for Neurodevelopmental Disorders
['FUNDING_FELLOWSHIP'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11077670
This study is looking at a special brain protein that plays a big role in conditions like autism, to see how changes in this protein and certain fats in the body might affect its function, which could help find new ways to improve symptoms for people with these challenges.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11077670 on ClinicalTrials.gov |
What this research studies
This research investigates the glycine receptor alpha 2 (GlyRα2), which is crucial for brain function and has been linked to neurodevelopmental disorders such as autism spectrum disorder. The study aims to explore how mutations in this receptor affect its function and how lipid molecules influence its activity. Using advanced techniques like cryogenic electron microscopy and patch-clamp electrophysiology, researchers will analyze the structural changes in GlyRα2 when it binds to glycine. This research could provide insights into potential therapeutic targets for improving symptoms in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related neurodevelopmental disorders.
Not a fit: Patients without neurodevelopmental disorders or those who do not have mutations affecting glycine receptors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate symptoms of autism spectrum disorder and related conditions.
How similar studies have performed: Previous research has shown promising results in understanding the role of glycine receptors in neurodevelopment, indicating that this approach has potential for success.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRUEGER, EMILY — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: KRUEGER, EMILY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.