Understanding how glycan sulfation affects neuroinflammation and Alzheimer's disease
Official title: Deciphering the Role of Glycan Sulfation in Neuroinflammation and Alzheimer's Disease
Funded at University of Washington · NIH-10900097 · Data updated 2026-11-12
This study is looking at how certain changes in sugar structures in the brain might affect inflammation and memory loss in Alzheimer's disease, with the hope of finding new ways to help improve brain health for people with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 25, 2025 |
| Project end | January 24, 2030 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AG087553-01 |
| Project ID | NIH-10900097 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals aged 65 and older who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
✕Less likely to help
Patients under the age of 65 or those without cognitive impairment may not benefit from this research.
What this research studies
This research investigates the role of glycan sulfation in the development and progression of Alzheimer's disease (AD). It focuses on how specific modifications in glycan structures, particularly in perineuronal nets, may influence neuroinflammation and cognitive decline. By examining the changes in these structures in the brains of older adults, the research aims to identify new therapeutic targets that could help stabilize neural circuits affected by AD. Patients may be involved in studies that explore these mechanisms and their implications for treatment.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve cognitive function and slow the progression of Alzheimer's disease.
How similar studies have gone: While the exploration of glycan sulfation in neuroinflammation is a relatively novel approach, similar studies have shown promise in understanding other neurodegenerative diseases.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Meuret, Cristiana Joy — University of Washington
- Study coordinator: Meuret, Cristiana Joy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.