Understanding how glutamate is transported into nerve cells
Official title: Glutamate Transport into Synaptic Vesicles
Funded at University of California, San Francisco · NIH-10991045 · Data updated 2026-11-12
This study looks at how a brain chemical called glutamate gets packed into tiny storage bubbles in nerve cells, which is really important for how brain cells talk to each other, and the findings could help improve treatments for conditions that affect brain signaling.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $443,708 |
| NIH project number | 5R01NS129803-03 |
| Project ID | NIH-10991045 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with neurological conditions that involve glutamate dysregulation.
✕Less likely to help
Patients with conditions unrelated to glutamate signaling or synaptic transmission may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms by which glutamate, a key neurotransmitter, is transported into synaptic vesicles in nerve cells. It focuses on how changes in ion gradients and other factors influence this transport process, which is crucial for effective communication between neurons. By studying the properties of vesicular glutamate transporters (VGLUTs) and their regulation, the research aims to uncover how these processes affect neurotransmission. Patients may benefit from insights gained about excitatory signaling in the brain, which could inform treatments for neurological conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for neurological disorders related to glutamate signaling.
How similar studies have gone: Previous research has shown success in understanding neurotransmitter transport mechanisms, indicating that this approach has a solid foundation.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Edwards, Robert H — University of California, San Francisco
- Study coordinator: Edwards, Robert H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.