Understanding how glucocorticoids affect pregnancy establishment
Uterine Glucocorticoid Signaling: a Critical Pathway in the Establishment of Pregnancy
This study is looking at how certain signals in the uterus affect the chances of getting pregnant and staying pregnant, especially for women who have experienced early pregnancy loss, to help find better ways to support successful pregnancies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11030314 on NIH RePORTER |
What this research studies
This research investigates the role of glucocorticoid signaling in the uterus and its impact on the establishment of pregnancy. By studying the cellular and molecular mechanisms involved in implantation, the researchers aim to uncover why many pregnancies fail, particularly focusing on immune system regulation. The study uses animal models to explore how the absence of glucocorticoid signaling leads to early pregnancy loss, which mirrors the experiences of many women. The findings could pave the way for new therapeutic strategies to improve implantation rates and pregnancy outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have experienced recurrent pregnancy loss or have difficulty with implantation.
Not a fit: Patients who are not trying to conceive or those with known genetic causes of infertility may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for women experiencing unexplained pregnancy loss.
How similar studies have performed: Other research has shown that understanding hormonal signaling pathways can lead to significant advancements in reproductive health, suggesting this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Whirledge, Shannon D — Yale University
- Study coordinator: Whirledge, Shannon D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.