Understanding how glucagon secretion is controlled in the pancreas
Regulation of Glucagon Secretion from Pancreatic Islets
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10912737
This study is looking at how certain signals in the body control the release of glucagon, a hormone that helps manage blood sugar levels, especially for people with diabetes, to find new ways to improve diabetes treatment and reduce complications.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10912737 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that regulate glucagon secretion from pancreatic alpha cells, which is crucial for maintaining blood sugar levels. The study aims to explore how different signaling pathways interact to control glucagon release, especially in the context of diabetes. By examining the role of other hormones like insulin and somatostatin, the research seeks to identify new strategies to normalize glucagon action and improve diabetes management. Patients may benefit from insights that could lead to innovative treatments for diabetes-related complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes, particularly those experiencing issues with glucagon regulation.
Not a fit: Patients without diabetes or those whose glucagon secretion is not a contributing factor to their condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help diabetic patients maintain stable blood sugar levels and reduce the risk of hypoglycemic episodes.
How similar studies have performed: Previous research has shown promising results in understanding hormone interactions in diabetes, suggesting that this approach could yield significant advancements.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PISTON, DAVID W — WASHINGTON UNIVERSITY
- Study coordinator: PISTON, DAVID W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.