Understanding how GLP-1 affects insulin and glucagon production during fasting
The effect of endogenous GLP-1 secretion on islet function in vivo
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-10839362
This study is looking at how a hormone called GLP-1 helps the pancreas work better during fasting and meals, which could lead to new ways to manage blood sugar for people with diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10839362 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a hormone called Glucagon-Like Peptide-1 (GLP-1) in regulating the function of insulin-producing beta cells and glucagon-producing alpha cells in the pancreas, particularly during fasting. By examining how GLP-1 signaling operates in both fasting and meal conditions, the study aims to uncover mechanisms that could improve glucose control in individuals with diabetes. The research will involve analyzing genetic variations that may influence how individuals respond to GLP-1 and its effects on blood sugar levels. This could lead to new insights into diabetes management and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with type 2 diabetes or those at risk of developing it.
Not a fit: Patients without diabetes or those with type 1 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for managing blood sugar levels in patients with diabetes.
How similar studies have performed: Previous research has shown promising results in understanding GLP-1's role in glucose regulation, indicating that this approach has potential for success.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VELLA, ADRIAN — MAYO CLINIC ROCHESTER
- Study coordinator: VELLA, ADRIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus