Understanding how GLIS3 affects pancreatic beta cell health in diabetes
Official title: Role of GLIS3 in Human Pancreatic Beta Cell Generation, Survival and Proliferation
Funded at Weill Medical Coll of Cornell Univ · NIH-10997338 · Data updated 2026-11-12
This study is looking at how a gene called GLIS3 affects the health and growth of insulin-producing cells in the pancreas, using human stem cells to see how different genetic changes related to diabetes might impact these cells, with the hope of finding new ways to help manage diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $563,271 |
| NIH project number | 5R01DK136005-02 |
| Project ID | NIH-10997338 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with type 1 or type 2 diabetes, particularly those with genetic variants affecting GLIS3.
✕Less likely to help
Patients without diabetes or those whose condition is unrelated to the genetic factors being studied may not benefit from this research.
What this research studies
This research investigates the role of the GLIS3 gene in the generation, survival, and proliferation of pancreatic beta cells, which are crucial for insulin production. By using human embryonic stem cells, the study aims to explore how genetic variants associated with diabetes impact these cells' function and health. The researchers will create specific cell lines to test how the absence of GLIS3 affects beta cell differentiation and survival, potentially identifying new therapeutic targets for diabetes management.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving pancreatic beta cell function in diabetes patients.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in diabetes, but the specific role of GLIS3 in this context is still being explored.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Chen, Shuibing — Weill Medical Coll of Cornell Univ
- Study coordinator: Chen, Shuibing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.