Understanding how GLIS3 affects kidney cyst formation
Official title: Regulation of GLIS3, a Ciliary Transcription Factor that Prevents Kidney Cysts
Funded at University of California, San Francisco · NIH-11115045 · Data updated 2026-11-12
This study is looking at how a protein called GLIS3 affects kidney cysts in people with Autosomal Dominant Polycystic Kidney Disease (ADPKD), with the hope of finding new ways to help improve treatment options for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | June 15, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $176,244 |
| NIH project number | 1K08DK143339-01 |
| Project ID | NIH-11115045 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with Autosomal Dominant Polycystic Kidney Disease.
✕Less likely to help
Patients with kidney diseases not related to ciliary dysfunction or those without a diagnosis of ADPKD may not benefit from this research.
What this research studies
This research investigates the role of GLIS3, a transcription factor, in the development of kidney cysts associated with Autosomal Dominant Polycystic Kidney Disease (ADPKD). The study aims to uncover the mechanisms by which GLIS3 influences signaling pathways related to kidney function and cyst formation. By examining the effects of mutations in key proteins involved in ciliary function, the research seeks to provide insights that could lead to new therapeutic strategies for patients with kidney diseases. Patients may benefit from a better understanding of their condition and potential new treatment options.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce kidney cyst formation in patients with ADPKD.
How similar studies have gone: Previous research has shown promising results in understanding ciliary functions in kidney diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Loeb, Gabriel B — University of California, San Francisco
- Study coordinator: Loeb, Gabriel B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.