Understanding how gliomas survive and evade treatment
Official title: Glioma intelligence from behind enemy lines
Funded at Mayo Clinic Rochester · NIH-11036290 · Data updated 2026-11-12
This study is looking at how gliomas, a type of brain tumor, manage to survive and resist treatment, and it aims to help find better ways to treat them by checking the tumor's chemistry during surgery for patients with gliomas.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $525,455 |
| NIH project number | 5R37CA276851-03 |
| Project ID | NIH-11036290 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with gliomas who are scheduled for surgical intervention.
✕Less likely to help
Patients with non-glioma brain tumors or those who are not undergoing surgery may not benefit from this research.
What this research studies
This research investigates the metabolic pathways that allow gliomas, a type of brain tumor, to survive and resist treatment. By using a technique called microdialysis, researchers will sample the tumor's microenvironment during surgery to gather real-time data on its biochemical processes. The goal is to identify specific metabolites that contribute to the tumor's resilience and to explore how these findings can inform new therapeutic strategies. Patients undergoing surgery for gliomas may have their tumor's metabolic activity monitored, providing insights that could lead to more effective treatments.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that improve treatment outcomes for patients with gliomas.
How similar studies have gone: Previous research has shown promise in using metabolic profiling to understand tumor behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Burns, Terry — Mayo Clinic Rochester
- Study coordinator: Burns, Terry
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.