Understanding how glioblastoma tumors grow and change over time
Modeling the Glioblastoma Microenvironment to Uncover Progression Mechanisms and Therapeutic Targets
This study is looking at how glioblastoma, a tough type of brain tumor, grows and changes, using special mouse models to help find new ways to treat it better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10829880 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the aggressive growth of glioblastoma, a severe type of brain tumor. By using advanced mouse models that mimic human gliomas, the team aims to study the tumor microenvironment and how it evolves, particularly focusing on areas of necrosis within the tumor. The researchers will employ multiphoton microscopy to observe these changes in real time, which could reveal new therapeutic targets and strategies for treatment. This approach seeks to deepen our understanding of how glioblastoma progresses and how it can be effectively treated.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma or those at risk of developing this aggressive brain tumor.
Not a fit: Patients with other types of brain tumors or those without a diagnosis of glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve outcomes for patients with glioblastoma.
How similar studies have performed: Previous research has shown promise in understanding tumor microenvironments in other cancers, suggesting that this approach could yield valuable insights for glioblastoma as well.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Brat, Daniel J — Northwestern University at Chicago
- Study coordinator: Brat, Daniel J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.