Understanding how glioblastoma invades and finding new treatments
Official title: Genetic and epigenetic mechanisms of glioblastoma invasion and their therapeutic implication
Funded at Yale University · NIH-11129602 · Data updated 2026-11-12
This study is looking at how certain genes might make glioblastoma, a tough brain tumor, grow and spread more aggressively, with the goal of finding new ways to treat it and help patients live better lives.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $32,974 |
| NIH project number | 5F31NS130942-02 |
| Project ID | NIH-11129602 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with glioblastoma who are seeking innovative treatment options.
✕Less likely to help
Patients with non-cancerous brain conditions or those who do not have glioblastoma may not benefit from this research.
What this research studies
This research investigates the genetic and epigenetic factors that contribute to the aggressive invasion of glioblastoma, a highly lethal brain tumor. By analyzing tissue samples from patients, the study aims to identify specific genes that promote tumor invasion and recurrence. The researchers will use advanced techniques like single-cell RNA sequencing to understand how these genes function and how they can be targeted for therapy. This work seeks to develop new treatment strategies that could improve outcomes for patients with glioblastoma.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates and quality of life for glioblastoma patients.
How similar studies have gone: Previous research has shown promise in targeting genetic factors in glioblastoma, suggesting that this approach could lead to meaningful advancements in treatment.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Long, Gretchen Irella — Yale University
- Study coordinator: Long, Gretchen Irella
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.