Understanding how glioblastoma interacts with brain environments through tiny vesicles
Official title: GLIOMA INTERACTION WITH THE NEUROGENIC NICHE THROUGH EXTRACELLULAR VESICLES
Funded at Mayo Clinic Jacksonville · NIH-10999368 · Data updated 2026-11-12
This study is looking at how an aggressive brain tumor called glioblastoma interacts with its surroundings and how tiny particles released by cells might affect the tumor's growth, with the hope of finding new ways to improve treatment for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $430,375 |
| NIH project number | 1R21NS128212-01A1 |
| Project ID | NIH-10999368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults diagnosed with glioblastoma, particularly those with tumors near the lateral ventricles.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not receive benefit from this research.
What this research studies
This research investigates the aggressive brain tumor glioblastoma (GBM) and its interaction with the neurogenic niche, particularly focusing on how extracellular vesicles influence tumor behavior. By examining the relationship between GBM and the surrounding brain structures, the study aims to uncover mechanisms that contribute to tumor growth and recurrence. Patients may benefit from insights that could lead to new therapeutic strategies targeting these interactions, potentially improving treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that reduce glioblastoma recurrence and improve patient survival rates.
How similar studies have gone: Previous research has shown promising results in understanding tumor interactions with the neurogenic niche, indicating potential for breakthroughs in treatment.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Guerrero-Cazares, Hugo — Mayo Clinic Jacksonville
- Study coordinator: Guerrero-Cazares, Hugo
Related research
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-
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This project uses a gene therapy that helps radiation work better against glioblastoma and builds computer models to predict where the therapy reaches after surgical tumor removal.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.