Understanding how glioblastoma cells move and invade brain tissue
Project 1
This study is looking at how different types of glioblastoma brain cancer cells move and spread into nearby brain tissue, using special mice to help find out what makes these types behave differently, which could help in figuring out better ways to treat the disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10896023 on NIH RePORTER |
What this research studies
This research investigates the movement of glioblastoma cells as they invade surrounding brain tissue, focusing on two main subtypes of the cancer. By using a genetically-induced mouse model, the researchers aim to identify mechanical characteristics that differentiate these subtypes and how they affect tumor behavior. The study employs advanced modeling techniques to analyze the migration patterns of cancer cells and immune cells, which are crucial for understanding tumor progression and potential treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma or glioblastoma multiforme.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets that specifically disrupt the invasive behavior of glioblastoma cells, improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promise in understanding cancer cell mechanics and their implications for treatment, suggesting that this approach could yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Odde, David J. — University of Minnesota
- Study coordinator: Odde, David J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.