Understanding how glioblastoma brain tumors use fats and cholesterol to grow
Determining the role of lipid droplets and their therapeutic potential in glioblastoma
This research explores how aggressive glioblastoma brain tumor cells manage fats and cholesterol to survive and grow, hoping to find new ways to stop them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11139413 on NIH RePORTER |
What this research studies
Glioblastoma is a very aggressive brain tumor with a poor outlook for patients. We know that these tumor cells take in and make a lot of fats and cholesterol to fuel their rapid growth. However, too much fat can be harmful to cells, so we are learning how glioblastoma cells protect themselves from this damage by storing excess fats in special compartments called lipid droplets. This project aims to understand how these cells also manage cholesterol and whether disrupting their ability to handle fats and cholesterol could lead to effective new treatments.
Who could benefit from this research
Good fit: This research is relevant for adult patients, 21 years or older, diagnosed with glioblastoma or other brain neoplasms.
Not a fit: Patients without glioblastoma or those who do not meet the age criteria would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that target how glioblastoma cells handle fats and cholesterol, potentially improving treatment options for patients.
How similar studies have performed: Previous work has shown progress in understanding how glioblastoma cells control fat balance, but the therapeutic disruption of lipid homeostasis is a novel approach being developed.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Guo, Deliang — Ohio State University
- Study coordinator: Guo, Deliang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.