Understanding how glioblastoma brain tumors change over time during treatment
Official title: Dissecting spatiotemporal heterogeneity of glioblastoma evolution under therapy
Funded at University of Miami School of Medicine · NIH-11013348 · Data updated 2026-11-12
This study is looking at how glioblastoma, a tough brain tumor, changes when treated, so we can find better ways to help patients whose tumors come back after treatment.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $113,995 |
| NIH project number | 5K99CA286730-02 |
| Project ID | NIH-11013348 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma, particularly those experiencing tumor recurrence after initial treatment.
✕Less likely to help
Patients with glioblastoma who are not undergoing treatment or those with other types of brain tumors may not benefit from this research.
What this research studies
This research investigates the evolution of glioblastoma, a highly aggressive brain tumor, particularly how it changes in response to various therapies. By analyzing the tumor's cellular makeup and the interactions between tumor cells and normal brain cells, the study aims to uncover the mechanisms that allow glioblastoma to resist treatment and progress. Utilizing advanced techniques like single-cell RNA sequencing, the researchers will explore the differences between primary and recurrent tumors to identify potential new therapeutic targets. This work is crucial for developing more effective treatments for patients with recurrent glioblastoma.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve outcomes for patients with glioblastoma.
How similar studies have gone: Previous research in cancer neuroscience has shown promise in understanding tumor behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Migliozzi, Simona — University of Miami School of Medicine
- Study coordinator: Migliozzi, Simona
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.