Understanding how glioblastoma affects the immune system
Regulating the glioma immune microenvironment
This study is looking at how immune cells in the brain interact with glioblastoma, a tough type of brain tumor, to find ways to boost the body's natural defenses against it, and it's for anyone affected by this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11059904 on NIH RePORTER |
What this research studies
This research investigates the immune microenvironment of glioblastoma, the most common and deadly brain tumor. It focuses on understanding how certain immune cells, like T cells and macrophages, interact with glioma cells and how a specific chemokine, CXCL14, can promote an effective immune response against the tumor. By analyzing human brain tumor samples and using advanced animal models, the research aims to identify ways to enhance anti-tumor immunity and overcome the tumor's immunosuppressive effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who may benefit from novel immunotherapy approaches.
Not a fit: Patients with other types of brain tumors or those not diagnosed with glioblastoma may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapy strategies that improve treatment outcomes for patients with glioblastoma.
How similar studies have performed: Previous research has shown promise in using immunotherapy to treat glioblastoma, indicating that this approach could lead to significant advancements.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Phillips, Joanna — University of California, San Francisco
- Study coordinator: Phillips, Joanna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.