Understanding how glioblastoma affects brain activity and vice versa
Official title: RECIPROCAL FEEDBACK MECHANISMS OF GLIOBLASTOMA AND NEURONAL NETWORK HYPEREXCITABILITY
Funded at Baylor College of Medicine · NIH-11019752 · Data updated 2026-11-12
This study is looking at how glioblastoma, a type of brain cancer, affects brain activity and causes seizures, with the hope of finding new ways to slow down the tumor and help improve the lives of patients dealing with both the cancer and epilepsy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | March 14, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $337,770 |
| NIH project number | 5R01CA263628-03 |
| Project ID | NIH-11019752 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who are experiencing tumor-related epilepsy.
✕Less likely to help
Patients with glioblastoma who do not experience seizures or those with other types of brain tumors may not benefit from this research.
What this research studies
This research investigates the complex relationship between glioblastoma, a type of brain cancer, and tumor-related epilepsy, which affects many patients with this condition. By using advanced imaging techniques and genetic models, the study aims to uncover how glioblastoma cells influence brain activity and how this interaction can lead to tumor growth. The goal is to identify potential therapeutic windows that could be targeted to slow down tumor progression and improve the quality of life for patients suffering from seizures. This approach is innovative as it combines cellular imaging with genetic manipulation to explore these mechanisms in a living organism.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that not only slow glioblastoma progression but also enhance the quality of life for patients by reducing seizure occurrences.
How similar studies have gone: Previous research has shown promising results in understanding the interactions between glioblastoma and neuronal activity, suggesting that this approach could yield significant insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Meyer, Jochen — Baylor College of Medicine
- Study coordinator: Meyer, Jochen
Related research
Other NIH-funded projects on the same topics.
-
Small molecules to block Slit2/ROBO in glioblastoma
A study to test small molecule drugs that block Slit2/ROBO signals to help treat glioblastoma in patients.
-
Immunotherapy for glioblastoma: advancing treatment and understanding
A patient-friendly summary of a grant exploring new immune-based treatments for glioblastoma to improve options for people affected by this brain cancer.
-
Small-molecule and biologic treatments for glioblastoma using targeted brain delivery
A new approach aims to use FPS-ZM1 to shrink brain swelling and support immunotherapy for glioblastoma, potentially helping patients recover after surgery.
-
Targeted therapies for glioblastoma in adults and kids
A large NIH program is exploring new brain cancer therapies, including drugs that reach the brain and work against glioblastoma in both children and adults.
-
6-thio-2'-deoxyguanosine for glioblastoma: a new approach to target tumors before surgery
A trial tests a novel drug given before glioblastoma surgery to see how it behaves in the body and within the tumor, and to learn how it affects cancer cells and the immune environment.
-
CD38-Driven Changes in Brain Tumor Metabolism and Immunity in Glioblastoma
A patient-facing look at how scientists plan to study how glioblastoma grows by changing its metabolism and dampening the immune response, with potential targets to help treatment in the future.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.