Understanding how glioblastoma adapts to low oxygen levels
Official title: Translation Regulation Contributes to Hypoxia Adaptation in Glioblastoma
Funded at Case Western Reserve University · NIH-10995386 · Data updated 2026-11-12
This study is looking at how glioblastoma, a tough type of brain cancer, survives in low oxygen levels, focusing on special cells that help the tumor grow, with the hope of finding better treatment options for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 17, 2024 |
| Project end | July 16, 2028 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 1F30CA294741-01 |
| Project ID | NIH-10995386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with glioblastoma who are seeking innovative treatment options.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research investigates the mechanisms by which glioblastoma, a highly aggressive brain tumor, adapts to low oxygen environments. The focus is on glioblastoma stem-like cells, which are believed to thrive in both low and normal oxygen conditions, contributing to the tumor's resilience and growth. By exploring the regulatory processes involved in protein production within these cells, the research aims to uncover new strategies for targeting glioblastoma more effectively. Patients may benefit from insights that could lead to improved treatment options for this challenging cancer.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve outcomes for patients with glioblastoma.
How similar studies have gone: While research on glioblastoma has been extensive, the specific focus on translation regulation in hypoxic conditions is relatively novel and has not been widely tested.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Dashora, Himanshu Rajeev — Case Western Reserve University
- Study coordinator: Dashora, Himanshu Rajeev
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.