Understanding how glial cells respond to brain injury
Exploring the Role Dense Core Vesicle Release in Glial Immunity
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-10874689
This study is looking at how certain brain cells called glial cells help protect and heal the brain when nerve cells get hurt, using fruit flies to understand the signals that trigger this healing process.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-10874689 on ClinicalTrials.gov |
What this research studies
This research investigates the immune responses of glial cells in the brain when neurons are damaged. By using the fruit fly as a model, the study aims to uncover the signals released by injured neurons that activate glial cells to clear away debris and promote healing. The researchers will explore how these signals are communicated and processed by glial cells to enhance their protective functions. This approach could provide insights into the mechanisms of neuroprotection and the role of glial cells in brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve neurodegeneration or brain injury.
Not a fit: Patients with non-neurological conditions or those who do not have any history of brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing brain repair and protecting against neurodegenerative diseases.
How similar studies have performed: Previous research has shown that understanding glial cell responses can lead to significant advancements in neuroprotection, indicating that this approach has potential for success.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOGAN, MARY ALLISON — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: LOGAN, MARY ALLISON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.