Understanding how glial cells interact with neurons in the nervous system
Molecular dissection of glia-neuron interactions
This study is looking at how brain cells work together to keep our nervous system healthy, using tiny worms to learn more about these important connections, especially as we age or in conditions like Alzheimer's and Autism, which could help improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11054724 on NIH RePORTER |
What this research studies
This research investigates the interactions between glial cells and neurons, which are crucial for maintaining nervous system health and function. By using the model organism C. elegans, the study aims to uncover the molecular mechanisms that govern these interactions, particularly at neuron endings where sensory information is processed. The research will explore how these interactions may change with age and in neurological diseases such as Alzheimer's and Autism. Patients may benefit from insights gained into how to improve or restore these critical cellular interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by neurological conditions such as Alzheimer's disease or Autism.
Not a fit: Patients with neurological conditions not related to glial-neuron interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurological diseases by enhancing glial-neuron interactions.
How similar studies have performed: Previous research has shown promising results in understanding glial functions in other model organisms, suggesting potential for success in this novel approach.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Singhvi, Aakanksha — Fred Hutchinson Cancer Center
- Study coordinator: Singhvi, Aakanksha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.