Understanding how glial cells interact around amyloid plaques in Alzheimer's disease
Dissect regulation of glial nets surrounding amyloid plaques in Alzheimer's disease
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11212223
This study is looking at how certain brain cells, called glial cells, interact with amyloid plaques in Alzheimer's disease, and it aims to see if blocking a specific gene can help reduce these plaques and inflammation, which could lead to new treatments for people with Alzheimer's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11212223 on ClinicalTrials.gov |
What this research studies
This research investigates the role of glial cells, specifically astrocytes and microglia, in the context of amyloid plaques associated with Alzheimer's disease. By examining the communication mechanisms within glial nets surrounding these plaques, the study aims to uncover how these interactions influence amyloid spreading and inflammation. The researchers will focus on a specific gene, Plexin-B1, which has been identified as crucial in regulating these glial interactions. Through experiments in mouse models, they will explore the potential of blocking Plexin-B1 to reduce amyloid burden and neuroinflammation, potentially leading to new therapeutic strategies for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at high risk for developing the condition.
Not a fit: Patients with non-Alzheimer's forms of dementia or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of Alzheimer's disease by reducing amyloid plaque burden and neuroinflammation.
How similar studies have performed: Previous research has shown promising results in targeting glial cell interactions in Alzheimer's models, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRIEDEL, ROLAND HORST — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: FRIEDEL, ROLAND HORST
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia