Understanding how glial cells influence the development and function of neurons
Glial Control of Neuron Development and Function
This study is looking at how special cells in the nervous system, called glial cells, work with nerve cells to help them function properly, using tiny worms as a model, and it aims to find new ways to help treat conditions related to nerve health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10990988 on NIH RePORTER |
What this research studies
This research investigates the role of glial cells in the development and functioning of the nervous system, focusing on how they interact with neurons. By using the model organism C. elegans, the study aims to uncover the mechanisms through which glia regulate neuronal activity and compartmentalization around synapses. The research seeks to fill gaps in knowledge regarding glial differentiation and their influence on neuronal plasticity and survival. Through this work, the researchers hope to identify new pathways that could be targeted for therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that may be influenced by glial cell function.
Not a fit: Patients with purely genetic neurological disorders unrelated to glial function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurological disorders by enhancing our understanding of neuron-glia interactions.
How similar studies have performed: Previous research has shown promising results in understanding glial functions in other model organisms, suggesting potential for success in this novel approach.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Shaham, Shai — Rockefeller University
- Study coordinator: Shaham, Shai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.