Understanding how glial cells help manage neuron health and death throughout life
Retooling innate immunity: An investigation of TLR-mediated glial priming across lifespan
This study is looking at how certain brain cells called glial cells help keep neurons healthy and deal with dying ones, which could help us understand brain health better and find new ways to treat diseases that affect the brain as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11001143 on NIH RePORTER |
What this research studies
This research investigates the role of a specific signaling pathway in glial cells that helps them manage the health and death of neurons. By examining how glial cells can switch between supporting neurons and removing dying ones, the study aims to uncover important mechanisms that influence brain health across different ages. The researchers will use advanced techniques to analyze how these glial cells interact with neurons and how they respond to signals indicating neuron death. This could lead to a better understanding of brain function and potential therapeutic targets for neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who may be experiencing neurological issues or are at risk for neurodegenerative diseases.
Not a fit: Patients with acute neurological injuries or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing brain health and treating neurodegenerative conditions.
How similar studies have performed: Previous research has shown promising results in understanding glial cell functions, but this specific approach is relatively novel and untested.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Broihier, Heather — Case Western Reserve University
- Study coordinator: Broihier, Heather
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.