Understanding how glial cells contribute to childhood brain tumors
Glial Origin and Signaling in Medulloblastoma
This study is looking at how certain brain cells might help medulloblastoma, a common brain tumor in kids, come back after treatment, with the hope of finding better ways to help children survive and feel better during their recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11026556 on NIH RePORTER |
What this research studies
This research investigates medulloblastoma, the most common malignant brain tumor in children, focusing on the role of glial progenitor cells in tumor recurrence. By analyzing tumor tissues at the single-cell level, the study aims to identify specific cell populations that contribute to the initiation and growth of these tumors. The researchers will explore how these glial cells behave during and after chemotherapy, potentially leading to new therapeutic strategies that target the root causes of tumor recurrence. The ultimate goal is to improve survival rates for affected children while reducing the side effects of treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with medulloblastoma, particularly those who have experienced tumor recurrence.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with medulloblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates for children with medulloblastoma.
How similar studies have performed: Previous research has shown promise in targeting specific cell populations in brain tumors, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Lu, Qing R — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Lu, Qing R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.