Understanding how glial cells affect hearing in a mouse model of Fragile X syndrome
Unraveling satellite glial cells dysfunctions in spiral ganglia of a mouse model of Fragile X syndrome
This study looks at how certain brain cells in mice with Fragile X syndrome affect hearing and sound processing, hoping to find out why some people with this condition have trouble with sensory experiences.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11045062 on NIH RePORTER |
What this research studies
This research investigates the role of satellite glial cells in the auditory system of a mouse model for Fragile X syndrome, a condition often associated with sensory processing issues. By examining how these glial cells influence the function of sensory neurons that transmit sound information to the brain, the study aims to uncover potential underlying mechanisms of sensory hypersensitivity and related behavioral challenges. The approach includes detailed analysis of neuronal communication and glial cell interactions, which could provide insights into the early sensory deficits observed in individuals with Fragile X syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fragile X syndrome or autism spectrum disorders who experience sensory hypersensitivity.
Not a fit: Patients without Fragile X syndrome or related sensory processing issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing sensory processing issues in patients with Fragile X syndrome and related disorders.
How similar studies have performed: While the specific focus on satellite glial cells in this context is novel, previous research has shown promising results in understanding sensory processing abnormalities in related neurodevelopmental disorders.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Cavalli, Valeria — Washington University
- Study coordinator: Cavalli, Valeria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.