Understanding how glial cells affect hearing in a mouse model of Fragile X syndrome
Official title: Unraveling satellite glial cells dysfunctions in spiral ganglia of a mouse model of Fragile X syndrome
Funded at Washington University · NIH-11045062 · Data updated 2026-11-12
This study looks at how certain brain cells in mice with Fragile X syndrome affect hearing and sound processing, hoping to find out why some people with this condition have trouble with sensory experiences.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $194,375 |
| NIH project number | 5R21DC021817-02 |
| Project ID | NIH-11045062 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Fragile X syndrome or autism spectrum disorders who experience sensory hypersensitivity.
✕Less likely to help
Patients without Fragile X syndrome or related sensory processing issues may not benefit from this research.
What this research studies
This research investigates the role of satellite glial cells in the auditory system of a mouse model for Fragile X syndrome, a condition often associated with sensory processing issues. By examining how these glial cells influence the function of sensory neurons that transmit sound information to the brain, the study aims to uncover potential underlying mechanisms of sensory hypersensitivity and related behavioral challenges. The approach includes detailed analysis of neuronal communication and glial cell interactions, which could provide insights into the early sensory deficits observed in individuals with Fragile X syndrome.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing sensory processing issues in patients with Fragile X syndrome and related disorders.
How similar studies have gone: While the specific focus on satellite glial cells in this context is novel, previous research has shown promising results in understanding sensory processing abnormalities in related neurodevelopmental disorders.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Cavalli, Valeria — Washington University
- Study coordinator: Cavalli, Valeria
Related research
Other NIH-funded projects on the same topics.
-
Understanding Fragile X Syndrome: How it progresses and affects daily life
A long-term study using existing Fragile X data to map how the condition changes over time in children and young adults, including how autism, race, and location influence outcomes.
-
Sleep and mood links in Fragile X Syndrome
A short, patient-friendly study to understand how sleep problems relate to mood and depressive symptoms in people with Fragile X–linked autism.
-
Connecting 3D genome misfolding to gene silencing in Fragile X syndrome
A study in people with Fragile X syndrome focuses on how 3D genome folding errors may turn off important genes, contributing to the condition’s features.
-
Cortical circuit problems in Fragile X mice and people
Researchers are studying how brain circuits go awry in Fragile X syndrome by comparing mice and people to understand why certain brain rhythms and responses are altered.
-
Brain biology in fragile X syndrome: how brain signals unfold and vary in patients
This grant supports research to understand brain signals and why symptoms vary in people with fragile X syndrome, aiming to translate findings into better care.
-
Brain research on Fragile X Syndrome to improve therapies
A multi-year program studies brain function and differences in Fragile X Syndrome to help develop better treatments for people with FXS.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.