Understanding how Gli3 protein regulates craniofacial development
Predicting Tissue Specific Gli3 Regulatory Activity Using Hand2
This study is looking at how a protein called Gli3 helps shape the lower jaw during development, which is important for a healthy face, and it aims to understand how this protein works to prevent certain birth defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-11054677 on NIH RePORTER |
What this research studies
This research investigates the role of the Gli3 protein in the development of the mandible, which is crucial for proper craniofacial formation. By examining how Gli3 functions as both an activator and repressor in the Hedgehog signaling pathway, the study aims to uncover the mechanisms that control its activity during embryonic development. The researchers will utilize engineered genetic tools to explore how chromatin accessibility and protein interactions influence Gli3's role in craniofacial syndromes. This work could provide insights into the biological processes underlying certain birth defects.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with craniofacial syndromes or those interested in the genetic factors influencing craniofacial development.
Not a fit: Patients without craniofacial conditions or those not affected by genetic factors related to Gli3 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for craniofacial syndromes and related birth defects.
How similar studies have performed: Previous research has shown promising results in understanding the role of transcription factors in developmental processes, indicating that this approach could yield valuable insights.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Peterson, Kevin Anthony — Jackson Laboratory
- Study coordinator: Peterson, Kevin Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.