Understanding how glaucoma affects nerve cells in the eye
Official title: Mechanisms of altered neuronal activity in experimental glaucoma
Funded at Yale University · NIH-10997737 · Data updated 2026-11-12
This study is looking at how glaucoma affects important cells in the eye that help us see, using mice to mimic the pressure and damage that happens in this condition, with the goal of finding new ways to protect vision for people with glaucoma.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2026 |
| Funding year | 2024 |
| Award (this year) | $460,625 |
| NIH project number | 1R21EY036705-01 |
| Project ID | NIH-10997737 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for glaucoma or those experiencing early signs of vision impairment.
✕Less likely to help
Patients with advanced glaucoma or those who have already experienced significant vision loss may not benefit from this research.
What this research studies
This research investigates the effects of glaucoma on retinal ganglion cells (RGCs), which are crucial for vision. By using mouse models that simulate increased pressure in the eye and direct injury to the optic nerve, the study aims to understand how these conditions alter the electrical activity of RGCs. The researchers will explore the cellular and synaptic mechanisms that lead to changes in RGC activity and identify different types of RGCs that respond differently to glaucoma. This work could provide insights into potential therapeutic targets for preserving vision in glaucoma patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing vision loss in patients with glaucoma.
How similar studies have gone: Previous research has shown promising results in understanding neuronal activity in glaucoma, indicating that this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Demb, Jonathan B — Yale University
- Study coordinator: Demb, Jonathan B
Related research
Other NIH-funded projects on the same topics.
-
IOP and CSF Pressure in Glaucoma Risk
This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.
-
Comparing tube positions in glaucoma implants to protect corneal cells
This trial compares two tube placements for glaucoma drainage implants to see which better protects corneal cells and controls eye pressure in people with uncontrolled glaucoma.
-
Automated topographic test for glaucoma detection and progression
A new automated method uses topographic structure-function mapping to help diagnose glaucoma earlier and track its progression in patients.
-
Using AI on eye scans and genes to predict glaucoma risk
This project uses artificial intelligence on eye scans, vision tests, and genetic information to find people most likely to develop or have worsening glaucoma.
-
AI-based glaucoma screening in community health centers
A new, easy-to-use AI screening approach will be tested in federally funded health centers to help identify people at risk for glaucoma, especially in communities with higher risk.
-
Understanding how glaucoma genes control eye cell function
A long-term research project will study how genetic factors affect eye cells in adults with glaucoma to uncover new ideas for protecting vision.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.