Understanding how glaucoma affects nerve cells in the eye
Mechanisms of altered neuronal activity in experimental glaucoma
['FUNDING_R21'] · YALE UNIVERSITY · NIH-10997737
This study is looking at how glaucoma affects important cells in the eye that help us see, using mice to mimic the pressure and damage that happens in this condition, with the goal of finding new ways to protect vision for people with glaucoma.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10997737 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of glaucoma on retinal ganglion cells (RGCs), which are crucial for vision. By using mouse models that simulate increased pressure in the eye and direct injury to the optic nerve, the study aims to understand how these conditions alter the electrical activity of RGCs. The researchers will explore the cellular and synaptic mechanisms that lead to changes in RGC activity and identify different types of RGCs that respond differently to glaucoma. This work could provide insights into potential therapeutic targets for preserving vision in glaucoma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for glaucoma or those experiencing early signs of vision impairment.
Not a fit: Patients with advanced glaucoma or those who have already experienced significant vision loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing vision loss in patients with glaucoma.
How similar studies have performed: Previous research has shown promising results in understanding neuronal activity in glaucoma, indicating that this approach has potential for success.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEMB, JONATHAN B — YALE UNIVERSITY
- Study coordinator: DEMB, JONATHAN B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.