Understanding how Gimap5 affects liver health
Official title: Investigating the role of endothelial Gimap5 in maintaining liver homeostasis
Funded at Yale University · NIH-10996246 · Data updated 2026-11-12
This study is looking at how problems with the Gimap5 gene might affect liver health and cause issues like portal hypertension, and it's for people with unexplained liver conditions to help find out more about their illness and improve diagnosis.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $33,958 |
| NIH project number | 1F30DK138640-01A1 |
| Project ID | NIH-10996246 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with unexplained liver disease, particularly those diagnosed with non-cirrhotic portal hypertension.
✕Less likely to help
Patients with liver diseases that have a well-defined etiology or those without any liver conditions may not benefit from this research.
What this research studies
This research investigates the role of the Gimap5 gene in liver health, particularly focusing on how its dysfunction can lead to liver diseases such as non-cirrhotic portal hypertension. The study utilizes whole exome sequencing to identify genetic mutations in patients with unexplained liver conditions. By examining mouse models, researchers will explore how the loss of Gimap5 affects liver sinusoidal endothelial cells, leading to changes in liver structure and function. This work aims to uncover the underlying mechanisms of liver disease and identify potential diagnostic markers.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for patients with liver diseases of unknown origin.
How similar studies have gone: Previous research has shown promising results in understanding liver diseases through genetic analysis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Brancale, Joseph — Yale University
- Study coordinator: Brancale, Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.