Understanding how germs share genes to become stronger
Determinants underlying horizontal gene transfer-mediated pathogen success
This project aims to understand how bacteria share genes, especially those that cause disease and resist antibiotics, to help us fight infections better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11136499 on NIH RePORTER |
What this research studies
Bacteria can share important genetic information, like instructions for resisting antibiotics, through a process called horizontal gene transfer. This sharing helps some germs become very successful at causing illness and makes them harder to treat. Our team wants to uncover why certain combinations of bacteria and shared genes thrive in different environments, including inside the human body. By learning these secrets, we hope to find new ways to stop harmful bacteria from spreading their resistance.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but its findings could eventually benefit anyone affected by antibiotic-resistant infections.
Not a fit: Patients seeking immediate new treatments or direct clinical care will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing the spread of antibiotic resistance and developing more effective treatments for infectious diseases.
How similar studies have performed: While the general process of gene transfer is known, this research explores the specific factors that make certain gene-sharing events lead to successful pathogens, which is a less understood area.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Lopatkin, Allison — University of Rochester
- Study coordinator: Lopatkin, Allison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.