Understanding how germ cells transition to become maternal contributions in embryos
Official title: Regulation of Germ cell to maternal transition
Funded at Icahn School of Medicine at Mount Sinai · NIH-10765423 · Data updated 2026-11-12
This study looks at how tiny cells in fruit flies turn into eggs, which are really important for making healthy embryos, and it aims to find out what helps or hinders this process to better understand fertility.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $594,133 |
| NIH project number | 1R35GM152236-01 |
| Project ID | NIH-10765423 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing infertility or difficulties in achieving pregnancy.
✕Less likely to help
Patients who are not trying to conceive or who have no fertility issues may not benefit from this research.
What this research studies
This research investigates the process by which germ cells transform into mature oocytes, which are essential for early embryo development. Using the fruit fly Drosophila as a model, the study focuses on the mechanisms that regulate this transition, particularly how certain genetic programs are silenced to ensure the proper formation of maternal contributions necessary for a healthy zygote. By exploring these biological processes, the research aims to uncover critical factors that could influence fertility and developmental success.
Why it matters
Potential benefit: If successful, this research could lead to new insights into fertility treatments and improve outcomes for individuals facing difficulties in conceiving.
How similar studies have gone: Other research has shown promising results in understanding germ cell development and its implications for fertility, indicating that this approach has potential for significant advancements.
Where this research is happening
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Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Rangan, Prashanth — Icahn School of Medicine at Mount Sinai
- Study coordinator: Rangan, Prashanth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.