Understanding how germ cells develop during early life stages
Regulation of Germ Cell Fate During Embryogenesis
['FUNDING_R37'] · JOHNS HOPKINS UNIVERSITY · NIH-10982495
This study looks at how tiny cells that are important for reproduction develop and change, using a small worm called C. elegans to learn more about the proteins that help control this process, which could help us understand similar processes in humans and other species.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10982495 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that determine the fate of germ cells, which are essential for reproduction. By studying the primordial germ cells in the model organism C. elegans, the researchers aim to uncover how specific proteins and structures influence cell differentiation and gene regulation. The project involves genetic analyses and the examination of RNA-binding proteins to understand their roles in preventing premature gene activation. This work could provide insights into fundamental biological processes that are relevant across many species, including humans.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with interests in reproductive health or developmental disorders.
Not a fit: Patients with conditions unrelated to germ cell development or those not interested in the biological mechanisms of reproduction may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of germ cell development, potentially leading to advancements in reproductive health and developmental biology.
How similar studies have performed: Other research has shown success in understanding germ cell development through similar genetic and molecular approaches, indicating that this area of study is both relevant and promising.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEYDOUX, GERALDINE CATHERINE JOELLE — JOHNS HOPKINS UNIVERSITY
- Study coordinator: SEYDOUX, GERALDINE CATHERINE JOELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.