Understanding how genomes change and maintain integrity over time
Functional Analysis of Programmed Genome Rearrangement
This study looks at how changes in the DNA of different animals, like lampreys and hagfish, happen over time and how these changes can impact health and reproduction, with the hope of finding helpful information for human health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11011811 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind changes in genome sequence, structure, and function, focusing on both evolutionary changes and those occurring during cell lineage development. By examining the genomes of various vertebrates, such as lampreys and hagfish, the study aims to uncover how these changes affect health and reproduction. The research employs comparative analysis and molecular biology techniques to explore the pathways that maintain genome integrity and how these insights could be applied to human health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or those interested in the evolutionary aspects of genome biology.
Not a fit: Patients with conditions unrelated to genomic integrity or those not interested in genetic research may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for maintaining genome integrity, potentially improving health outcomes and reproductive success in humans.
How similar studies have performed: Other research has shown success in understanding genome biology through comparative studies in vertebrates, suggesting that this approach could yield valuable insights.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Smith, Jeramiah James — University of Kentucky
- Study coordinator: Smith, Jeramiah James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.