Understanding how genome structure changes over time
Computational tools and quantitative analyses of genome structure evolution
['FUNDING_OTHER'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-10866552
This study is looking at how changes in the structure of chromosomes, especially in sex chromosomes, can affect traits like disease risk and reproduction, and it’s creating a user-friendly software tool to help researchers better understand these genetic variations, which could be really helpful for studying organisms like malaria mosquitoes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-10866552 on ClinicalTrials.gov |
What this research studies
This research investigates the evolutionary forces that drive changes in genome structure, particularly focusing on chromosome inversions and sex chromosomes. By developing an open-source software package, the research aims to simulate whole chromosomes with polymorphic inversions, allowing for a detailed analysis of how these variations affect traits such as disease susceptibility and reproductive success. The findings could enhance our understanding of genetic variation and its implications for adaptation and speciation in organisms like the malaria mosquito.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or those affected by diseases influenced by chromosomal variations.
Not a fit: Patients with conditions unrelated to genetic variations or chromosomal structure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic variations that influence health and disease, potentially informing future treatments.
How similar studies have performed: Other research has shown success in using computational tools to analyze genetic variations, indicating that this approach has potential for meaningful insights.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUERRERO, RAFAEL F — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: GUERRERO, RAFAEL F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.