Understanding how genome stability affects brain health and disease
Genome Stability in Glia & Disease
This study is looking at how problems with DNA in brain-supporting cells might lead to issues like neurodegeneration and brain tumors, with the hope that understanding these connections can help develop new treatments for people facing these challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10874722 on NIH RePORTER |
What this research studies
This research investigates the role of genome stability in glial cells and its impact on various neurological diseases. By examining how defects in DNA damage responses contribute to conditions like neurodegeneration and brain tumors, the study aims to uncover the mechanisms linking genome instability to brain health. The approach includes advanced techniques such as ATAC sequencing to analyze chromatin accessibility and gene expression in glial cells, which are crucial for maintaining brain function. Patients may benefit from insights that could lead to new therapeutic strategies for conditions associated with DNA repair deficiencies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with inherited DNA repair deficiency syndromes, neurodevelopmental disorders, or brain tumors.
Not a fit: Patients with conditions unrelated to DNA damage responses or those without neurological involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with neurodegenerative diseases and brain tumors.
How similar studies have performed: Previous research has shown promising results in understanding the links between genome instability and neurological diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Mckinnon, Peter J — St. Jude Children's Research Hospital
- Study coordinator: Mckinnon, Peter J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.