Understanding how genome organization during early development affects birth defects
Dynamics of lineage-specific genome reorganization in gastrulation and their response to disease-associated epigenetic perturbations
This study is looking at how cells change and organize themselves during early human development, which is important for preventing birth defects, and it aims to help us understand what goes wrong when things don’t develop as they should.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10914004 on NIH RePORTER |
What this research studies
This research investigates the critical process of gastrulation, where cells differentiate into the primary germ layers that form the human body. It focuses on how the three-dimensional (3D) organization of the genome changes during this process and how disruptions in these changes can lead to birth defects. By using advanced techniques like proximity ligation assays, the research aims to uncover the mechanisms behind these genomic reorganizations and their implications for cell fate and development. This could provide insights into the causes of congenital abnormalities and improve our understanding of early human development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of congenital abnormalities or those who have experienced pregnancy complications related to developmental issues.
Not a fit: Patients who are not pregnant or do not have a history of congenital abnormalities may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for birth defects and other developmental disorders.
How similar studies have performed: Previous research has shown promising results in understanding genome organization and its impact on development, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Kalhor, Reza — Johns Hopkins University
- Study coordinator: Kalhor, Reza
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.