Understanding how genome instability contributes to cancer development
Properties and mechanisms of punctuated genome instability
This study is looking at how short periods of genetic changes in cells can cause multiple mutations that might lead to cancer, using yeast as a model to help us understand how these changes happen and what they mean for cancer growth, which could help improve future treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10893443 on NIH RePORTER |
What this research studies
This research investigates how temporary episodes of genome instability can lead to multiple mutations in cells, particularly in the context of cancer. By using the budding yeast model, the study aims to explore the timing and causes of these destabilizing events, which are believed to play a significant role in cancer progression. The researchers will employ advanced genomic and cellular techniques to analyze these bursts of instability, providing insights into the mechanisms behind cancer development. This work could enhance our understanding of how certain cancers evolve and may inform future therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those diagnosed with cancers that exhibit genomic instability.
Not a fit: Patients with stable genomes or those whose cancers are not associated with genomic instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating various types of cancer by targeting the mechanisms of genome instability.
How similar studies have performed: Other research has shown promising results in understanding genomic instability in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Heasley, Lydia Rene — University of Colorado Denver
- Study coordinator: Heasley, Lydia Rene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.