Understanding how genome folding affects gene activity
Investigating the role of genome folding in transcriptional regulation
This study is looking at how the way DNA is folded in our cells affects how genes work, focusing on a special protein that helps shape this DNA, and it's aimed at helping us understand how these changes can lead to health issues like cancer and developmental disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10874480 on NIH RePORTER |
What this research studies
This research investigates how the folding of DNA within the cell nucleus influences the regulation of gene activity. By focusing on the role of a protein complex called cohesin, which helps form loops in the DNA, the study aims to uncover the mechanisms that link DNA structure to gene expression. Researchers will use advanced tools to manipulate these processes in mouse embryonic stem cells, providing insights into how changes in genome folding can lead to diseases like cancer and developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations linked to developmental disorders or certain types of cancer.
Not a fit: Patients with conditions unrelated to chromatin architecture or transcription regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases caused by mutations in genome folding.
How similar studies have performed: Other research has shown promising results in understanding the role of chromatin structure in gene regulation, making this approach both relevant and potentially impactful.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Nora, Elphege-Pierre Julien — University of California, San Francisco
- Study coordinator: Nora, Elphege-Pierre Julien
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.